The Consensus Panel Recommendations from the Second International Workshop on Waldenström’s Macroglobulinemia (WM) [1] state that the diagnosis of WM requires the following clinical and pathological criteria: presence of infiltration of clonal lymphoplasmacytoid cells documented by bone marrow (BM) biopsy (lymphoplasmacytic lymphoma (LPL)) and presence of monoclonal IgM in the serum, irrespective of the M-protein size. The gene discussed is CD40LG; the disease is Waldenstrom macroglobulinemia.