NRAS and breast cancer: Transcriptome profiling of MBM and normal brain controls (Cortex, Pons, Cerebellum/Cereb; BC; Supplementary Data 2) revealed a separation regarding molecular features and the content of admixed brain parenchyma, irrespective of the intracranial region or genetic state (presence of BRAF or NRAS mutations) of tumors (Fig. 2b).