Transcriptome profiling of MBM and normal brain controls (Cortex, Pons, Cerebellum/Cereb; BC; Supplementary Data 2) revealed a separation regarding molecular features and the content of admixed brain parenchyma, irrespective of the intracranial region or genetic state (presence of BRAF or NRAS mutations) of tumors (Fig. 2b). This evidence concerns the gene BRAF and breast cancer.