GSEA unraveled the molecular features of Ecad+ and NGFR+ tumors (Supplementary Data 4) and revealed a proliferative phenotype of Ecadpos tumor cells (Fig. 3c, left panel) and enrichment of a tumor-intrinsic NGFR-signature that was derived from a set of melanoma cell lines which had spontaneously acquired resistance to T cells in Ecadlow/NGFRhigh tumors (Supplementary Fig. 4a). This evidence concerns the gene NGFR and melanoma.