Considering that the expression of NGFR in melanoma cells accompanies a network of associated genes such as mediators of a NCSC-phenotype34,92,93 - which was recently identified as a major driver of MRD24 - we propose that the upregulation of NGFR and associated genes may indicate the fate of relapse in the brain and intracranial progression. This evidence concerns the gene NGFR and melanoma.