Apart from extrinsic apoptosis and necroptosis, interestingly, a recent study showed that CD8+ T-cells sensitize cancer cells to ferroptosis through IFN-γ-induced downregulation of xCT during immune checkpoint blockade [70], strongly suggesting ferroptosis to be a type of cell death naturally occurring in the tumor microenvironment which might be instrumental to immune cell-mediated “selection-of-the-fittest” even in the absence of immunotherapy. Here, CD8A is linked to neoplasm.