Interestingly, the phosphorylation sites identified (Ser1316/Ser1320) also lie in the conserved β-TrCP degradation motif (DSGXXS degron), and β-TRCP, an E3 ligase that preferentially binds to phosphorylated substrates, is known to degrade ARID1A in gastric cancer cells44. This evidence concerns the gene ARID1A and gastric cancer.