To assess ARID1A in PCa, we first compared ARID1A expression in prostate lysates derived from WT mice or mice harboring ProbasinCre/+-mediated deletion of Pten (PtenPC−/−) or Pten/Trp53 (PtenPC−/−; Trp53PC−/−), representing indolent tumors or metastatic PCa, respectively. Here, PTEN is linked to posterior cortical atrophy.