According to staining for Ki67, SMAα, CD8 and Ly6G and FACS analysis, tumor remnants in anti-Ly6G-treated PtenPC−/−; Arid1aPC−/− mice exhibited reduced proliferation and stromal reactions, accompanied by increased total and IFNγ+ CD8+ T cells (Fig. 2g and Supplementary Fig. 2j, k). This evidence concerns the gene CD8A and neoplasm.