Consistent with a previous report showing that β-catenin can directly induce VEGF expression in human colon cancer cells [31], we found that β-catenin activation by AKT-mediated β-catenin S552 phosphorylation had an important function in EGFR activation-induced VEGF transcription in a PFKP Y64 phosphorylation-dependent manner in GBM. This evidence concerns the gene EGFR and malignant colon neoplasm.