CEP135 and neoplasm: Notably, observed in our settings downregulation of CEP135 in DNA repair diseases (Fig. 2D) is likely to be related to the cell cycle alterations that occur in premature aging, while its elevated expression in cancer goes in line with the known function of CEP135 in centrosome biogenesis and associated cancer-related abnormalities, including centrosome amplification and subsequent tumor progression [39].