Moreover, a recent study by Wang and Zhuang showed that Rho family small G protein Cdc42 is a convergent node of multiple regulatory signals that occur in MVs biogenesis and the binding of activated GTP-bound Cdc42 and its downstream effector, Ras GTPase-activating-like protein 1 (IQGAP1), is required for MVs shedding in breast cancer cells [113]. Here, CDC42 is linked to breast carcinoma.