Interestingly, unlike the hindbrain neuronal inclusions observed in TgM83+/− mice, Tg(SNCA*A53T+/+)Nbm mice developed pathology primarily in limbic system neurons with some additional astrocytic pathology, reminiscent of inclusions found in astrocytes in the brainstem, spinal cord and periventricular regions of long duration MSA patient brains [85, 113–115]. The gene discussed is SNCA; the disease is multiple system atrophy.