To further investigate the effects of circLOC101928570 on SLE, we verified that it was markedly downregulated in PBMCs of 62 SLE patients versus 62 healthy controls, we also checked the expression of circLOC101928570 in CD4 + and CD8 + T cells isolated by magnetic activated cell sorting (MACS) from the PBMCs of SLE patients and healthy controls. The gene discussed is CD8A; the disease is systemic lupus erythematosus.