GRN and Hepatic fibrosis: Emodin can lessen the severity of liver fibrosis by decreasing the infiltration of Gr1hi monocytes and drastically reducing the production of granulin (GRN), monocyte chemoattractant protein 1 (MCP-1), TNF-α, TGF-β1, and chemokine ligand 7 (CCL7) in the liver [135].