TGF-βIR can phosphorylate SMAD2 and SMAD3, which suggests that phosphorylation of SMAD2 and SMAD3, is required for the smooth transmission of the TGF-β signaling pathway and thus its activation and accelerating the development of liver fibrosis [37, 38]. The gene discussed is TGFB1; the disease is Hepatic fibrosis.