Among the 40 potential targets of the VEGF signaling pathway, VEGFA, NOS3, JUN, PTGS2, SLC6A3, BCL2L1, PRKACA, CASP9, BAX, and F2 were considered to be high-degree targets for Angelicae Pubescentis Radix and, thus, important targets for the treatment of RA. This evidence concerns the gene NOS3 and rheumatoid arthritis.