The core genes were mainly enriched in the pathways of calcium signaling, amphetamine addiction, cocaine addiction, neuroactive ligand-receptor interaction, cholinergic synapse, serotonergic synapse, morphine addiction, salivation, adrenergic signaling in cardiomyocytes, advanced glycation end products-recombinant advanced glycation end products (AGE-RAGE) signaling in diabetic complications, vascular endothelial growth factor signaling, apoptosis of multiple species, Parkinson’s disease, platinum drug resistance, and pancreatic cancer (Figs. 6 and 7). Here, VEGFA is linked to familial pancreatic carcinoma.