Overall, the mRNA levels of ACVR1, STAT3, WNT5A, KLF4 and DMC1 were obviously decreased in glioma samples with 1p19q codeletion compared to those in glioma samples without 1p19q codeletion (Fig. 5A–C, and Additional file 1: Fig. S7, Table S6). The gene discussed is KLF4; the disease is central nervous system cancer.