Overall, the mRNA levels of ACVR1, STAT3, WNT5A, KLF4 and DMC1 were obviously decreased in glioma samples with 1p19q codeletion compared to those in glioma samples without 1p19q codeletion (Fig. 5A–C, and Additional file 1: Fig. S7, Table S6). Here, ACVR1 is linked to central nervous system cancer.