Notably, it was shown that some core oncogenes/tumour suppressors strongly upregulated/repressed IPS reprogramming (TP53, RB, MYC) [45], PGC-like cell formation (TP53), PGC-EGC conversion (TP53, PTEN) [9], meiosis (TP53) [51] and primary oocyte maturation (TP53) [20, 52], which further supported the essential role of the embryonic/germ cell-like cycle in malignant tumour prognosis [53]. Here, RB1 is linked to cancer.