Although the mRNA levels of SOX17, a core germ cell specification gene [38], were enriched in some gliomas, they did not show obvious correlations with advanced pathologic grades and poor outcomes (Figs. 3B and D and 4C, D and Additional file 1: Fig. S5B, S6A, Table S3–S5), likely because SOX17 also inhibits PGC-EGC reprogramming [33]. The gene discussed is SOX17; the disease is glioma.