The data showed that IPS reprogramming factors and pluripotency-related genes (POU5F1, SOX2, KLF4, MYC and NOTCH1) were detected in almost all histologic types and grades of gliomas (Fig. 3A, B, and Additional file 1: Fig. S4A, S5A, Table S3–S5). This evidence concerns the gene NOTCH1 and central nervous system cancer.