KEGG pathway analysis of DASGs showed that the top 10 enriched pathways were Pathway in cancer, Fc epsilon RI signalling, Chronic myeloid leukemia, ErbB signalling, B cell receptor signalling, Neurotrophin signalling, Prolactin signalling, T cell receptor signalling, HIF-1 signalling and Renal cell carcinoma, as shown in Fig. 3c. Here, EGFR is linked to hereditary clear cell renal cell carcinoma.