TLR4 and heart failure: In this study, the inhibition of TLR4 expression levels was further demonstrated by meta-analysis, improving the degree of cardiac failure with a significant reduction in heart mass ratio (HW/BW, SMD = 1.9; 95% CI [0.59, 3.21], p = 0.004), a significant reduction in impaired LVSP (SMD = -2.39; 95% CI [- 4.32, -0.46], p = 0.02), and a significant reduction in LVEDP (SMD = 2.88; 95% CI [1.05, 4.71], p = 0.002).