NFKB1 and cardiovascular disorder: Numerous studies have shown that the TLR4/NF-κB signaling pathway is closely associated with the development of cardiovascular disease, and the TLR4 protein can enter the nucleus via the intracellular transport pathway, thereby leading to the activation of NF-κB and release induction of substantial amounts of inflammatory factors from cells, resulting in the development of an inflammatory response that causes myocardial cell necrosis, increased myocardial infarct size, and reduced cardiac function.5, 6, 7, 8