Classification of atopic and non‐atopic asthma was based on different methods including fractional exhaled nitric oxide measurements,17 having allergic rhinitis in combination with use of allergy medication or reported allergic symptoms,18 positive skin prick test,13 or investigated allergic sensitization defined as specific IgE positivity to one or more inhalant allergens19 (Supplementary Results S1). This evidence concerns the gene IGHE and allergic disease.