Youden index demonstrated crystalline CLC structure higher than 1 per high power field can predict postoperative polyp recurrence with 84.80% sensitivity and 98.70% specificity.<h4>Conclusions</h4>The crystalline CLC structures in nasal tissues may serve as an easy-counting and promising biomarker to predict CRSwNP recurrence. This evidence concerns the gene CLC and chronic rhinosinusitis with nasal polyps.