Furthermore, one lncRNA, LOC100132686, was significantly downregulated, and its potential target interleukin 18 has been identified as an important cytokine in the defenses against Cryptosporidium infection [52, 53], suggesting that potential target genes of dysregulated lncRNAs might play important roles in regulation of the interaction between host cells and C. parvum. This evidence concerns the gene IL18 and cryptosporidiosis.