Studies have shown that CXCL1 tends to be highly expressed in tumor cells with low T cell clones, that CXCL1 production promotes the recruitment of MDSCs into the tumor, thereby inhibiting CD8 + T cell infiltration, and that CXCL1 production by tumor cells is required for an immunosuppressive phenotype [31]. This evidence concerns the gene CXCL1 and neoplasm.