PLK1 and central nervous system cancer: Moreover, several NP-mediated short nucleotide chain (RNA) delivery systems have been formulated for the glioma gene therapy techniques, directing a range of genes: Bcl2L12, c-Met, epidermal growth factor receptor (EGFR), Polo-like kinase-1 (PLK1), miRNA-21, VEGF, special AT-rich sequence-binding protein-1 (SATB1 protein), and Galectin-1 [141–143].