In breast cancer, the results proved that Bif-1 expression was positively related to the infiltration of purity (r = − 0.176, 2.37e−08), B cells (r = 0.139, p = 1.32e−05), CD8+ T (r = 0.446, p = 8.65e−49), CD4+ T cells (r = 0.246, p = 1.13e−14), macrophages (r = 0.391, p = 2.57e−37), neutrophils (r = 0.399, p = 1.36e37), and DCs (r = 0.308, p = 2.43e−22). Here, SH3GLB1 is linked to breast cancer.