Thus, some tumor cells showed only enteroblastic differentiation, and some tumor cells did only neuroendocrine feature, but other tumor cells were positive for both enteroblastic differentiation markers and neuroendocrine differentiation markers, indicating amphicrine cells (Fig. 4a, H&E; b, SALL4 immunohistochemistry; c, synaptophysin immunohistochemistry). The gene discussed is SALL4; the disease is neoplasm.