Further pathway enrichment indicated that, in concordant with the fast cell proliferation rates of PANC-1-HOGA1-KD, we found proteins that enriched in cell cycle process, DNA repair process showed significantly enhanced expression in PANC-1-HOGA1-KD, and decreased expression in PANC-1-HOGA1-OE, comparing to wild type PANC-1, suggested HOGA1 might impact tumor cell proliferation process (Additional file 21: Fig. S21B, Additional file 30: Table S8K). Here, HOGA1 is linked to neoplasm.