To determine whether the metabolic enzymatic activity of HOGA1 is important for the expansion of tumor cells, we treated PANC-1 and BxPC-3 cells with hydroxyproline and glyoxylate, respectively, and found the neither of them affected the cell proliferation (Additional file 20: Fig. S20E, Additional file 30: Table S8D). Here, HOGA1 is linked to neoplasm.