IRF6 and neoplasm: As a result, the most significant positive correlations were observed between MCM4 (TG of IRF6) with both MGPS (correlation = 0.47, P = 6.7E−14) and tumor size (correlation = 0.25, P = 0.04), emphasized the important role of MCM4 in IRF6-mediated cell proliferation (Fig. 2J, K).