In a GWAS for ACPA-positive RA patients with radiographic joint damage, Knevel et al. [21] reported that a cluster of single nucleotide polymorphisms (SNPs), including rs7607479 (C/T) and rs6435818 (A/C), were associated with the radiological progression rate of RA in European and North American patients. The gene discussed is PRTN3; the disease is rheumatoid arthritis.