Hence, besides BRAFV600E mutation, the selected cell lines carry some of the most relevant mutations in melanoma, including missense mutations (MaMel86b) or loss of heterozygosity (MaMel63a) in TP53, and CDKN2A (MaMel19) and PTEN (MaMel21) biallelic deletions [17]. Here, CDKN2A is linked to melanoma.