AKT1 and melanoma: We infer a multistage and multifactorial nature of the oncogenic progression during the acquisition of drug resistance in melanoma, marked by the loss of cell differentiation, increased quiescence and migratory potential, reduced dependency on MAPK/ERK pathway, and activation of phosphatidylinositol 3‐kinase/protein kinase B (PI3K/AKT) signaling.