We found that in tumor tissues with circ_0017109 knockdown, FZD4, β-catenin and non-phospho β-catenin, cyclin D1, and c-Myc showed significant reduction, and a higher level of cleaved caspase-3 and a lower level of Bcl-2 were also detected (Fig. 6C). Here, BCL2 is linked to neoplasm.