Moreover, MT activates the JAK2/Stat3 pathway through increasing p-Stat3 and p-JAK2 levels in myocardial ischemia/reperfusion [48], and the binding relation between miR-15a-5p and Stat3 in human umbilical vein fusion cells is also confirmed by Li et al. [49]. The gene discussed is STAT3; the disease is myocardial ischemia.