When we compared the pancreatitis gene set with that of the housekeeping gene, TpA and CpG dinucleotides were found underrepresented in both the gene sets; in the pancreatitis gene set we revealed the underrepresentation of CpG in most of the genes, excluding CDKN2A and von Hippel-Lindau tumor suppressor (VHL) genes where CpG was overrepresented and in Apolipoprotein A5 (APOA5) and Multiple endocrine neoplasia type 1 (MEN1) where CpG was randomly used. This evidence concerns the gene VHL and multiple endocrine neoplasia type 1.