CD4 and lung carcinoma: Furthermore, we set up an additional group using NCI-H1975/Beas-2B cells treated with CD4+ T cell conditioned medium pretreated with 30 μg/mL propofol + 100 μM bicuculline (B group), and observed a reversal effect of propofol on inhibiting lung cancer viability, invasion, and migration by addition of bicuculline (all p < 0.001, Fig. 3A–D), which suggested that propofol affected lung cancer cell migration and invarion by affecting Th17/Treg cell balance through GABAA receptor.