After examining the effect of an ATM kinase inhibitor (ATMi) in a panel of tumor cell lines including human U87 and U1242 glioma cells as well as HEK293 and HEK293T carcinoma cells, inhibition of AKT phosphorylation was observed across the board relative to untreated cells with the exception of HEK293T cells (Fig. S1B). Here, AKT1 is linked to central nervous system cancer.