A heatmap of genes that had significantly different expression levels between responders and nonresponders from this immune gene cluster reveals increases in genes that encode for proteins known to increase T cell trafficking to tumors (CCL21), transendothelial migration (SELE), tumor cell killing (GZMB) and antigen presentation (HLA-DRB1) (Fig. 2f). The gene discussed is HLA-DRB1; the disease is neoplasm.