Lately research that revealed deletion of PDPN in glioma cells resulted in a significant reduction of intratumoral platelet aggregates in vivo preliminarily confirmed the hypothesis [46].On the other hand, herein, we found that PDPN knockdown can directly reduce the ability of GBM cell to induce TAM and TAN infiltration and polarization toward M2 or N2 type in vitro, which has never been reported before. Here, PDPN is linked to central nervous system cancer.