We demonstrate that PDPN is involved in the formation of glioma progression IME: GSEA results in our study suggested PDPN correlated gene set highly enriched the adaptive immunity, negative regulation of T cell activation and negative regulation of lymphocyte activation (Fig. 5E), and neutrophil degranulation and Interleukin-4 and Interleukin-13 signaling (Fig. 6A, B). The gene discussed is IL4; the disease is central nervous system cancer.