IDH1 and central nervous system neoplasm: According to the latest WHO classification of CNS tumors, IDH wildtype diffuse glioma with histological appearance of necrosis or microvascular proliferation, or genetic alterations as TERT promoter mutation, EGFR amplification, or Chr 7 Gain and Chr 10 Loss should be diagnosed as “Glioblastoma, IDH wildtype” [6–8].