Notably, we observed a positive correlation of expression of GPSM1 in visceral fat with clinical quantitative traits indicating obesity and glucose metabolism, such as BMI, Fasting plasma glucose (FPG), HbA1c, as well as biochemical indicators, including TC, LDL-c, ALT, and AST (Fig. 10c). The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.