Overall, together with the observations that GPSM1-deficient mice were protected from developing diet-induced obesity and glucose and lipid dysregulation, our results strongly suggest that increased GPSM1 expression in human visceral fat may be causally linked to the pathogenesis of obesity, T2D, and metabolic disturbances. The gene discussed is GPSM1; the disease is obesity due to melanocortin 4 receptor deficiency.