To elucidate the role of macrophage GPSM1 in the pathogenesis of metabolic disorders, we intercrossed mice bearing a conditional loxP-flanked (‘floxed’) allele of GPSM1 (GPSM1f/f, used as control mice) with the Lysozyme 2-Cre (Lyz2-Cre) line18 to create myeloid-specific GPSM1-knockout (GPSM1f/f; Lyz2-Cre) mice. Here, LYZ is linked to metabolic disease.