As leukocytosis and monocytosis promote metabolic inflammation19–21, we first examined whether myeloid GPSM1 loss could affect the proliferation of the Lin−Sca1−cKit+ myeloid progenitors (MPCs) in the bone marrow or blood leukocyte counts and monocyte subset distribution. The gene discussed is GPSM1; the disease is Increased total leukocyte count.