A second inflammasome that is relevant in MPN is the Absence In Melanoma 2 (AIM2) inflammasome that recognizes double-stranded DNA, functioning to protect against pathogens and dsDNA released from apoptotic or dying cells, which in turn leads to the release of proinflammatory cytokines and sterile inflammation [99]. This evidence concerns the gene AIM2 and myeloproliferative disorder.