Increased levels of IL-33 are demonstrable in the bone marrow and splenic vascular endothelium of MPN patients compared to controls, similar to expression of its accessory receptor ST2, also known as IL1RL1, which is necessary for IL-33 binding to the receptor complex and is upregulated in CD34 + HSPCs [69]. Here, IL33 is linked to myeloproliferative neoplasm.