Another study also showed that mutations in NF-E2 were detected in MPN patients who harbored JAK2V617F, provided a proliferative advantage to the doubly mutant clone; and in a murine model, NF-E2 mutations caused a myeloproliferative phenotype (erythrocytosis and thrombocytosis) while predisposing to leukemic transformation [115]. Here, NFE2 is linked to polycythemia.