For the cancer cell subtypes, we found that compared with Clara-like cancer cells (Epi-C1) and CRABP2 + cancer cells (Epi-C3), the proportions of both TM4SF1 + (Epi-C0) and UBE2C + (Epi-C6) cancer cells were constantly increased during the invasive process of LUAD and dramatically elevated in IAC. The gene discussed is TM4SF1; the disease is cancer.