These identified genome-wide associations between severe COVID-19 and gene clusters in IFNAR2 (subunit of IFN receptor), near the gene encoding tyrosine kinase 2 (TYK2) (associates with plasma domain of IFNAR), and in a gene cluster encoding antiviral restriction enzyme activators (OAS1, OAS2, OAS3) (induced by IFN-I)27. Here, IFNAR1 is linked to COVID-19.