These four gene-cancer pairs were EWSR1 (26.3% vs. 13.0%) and FLI1 in bone cancer (23.2% vs. 9.6%), BRAF in glioma (3.6% vs. 0.4%), and TEF3 in renal cell carcinoma (8.5% vs. 1.7%). This evidence concerns the gene FLI1 and central nervous system cancer.