In support of this, higher levels of PROX1 were observed in KRAS-driven LKB1-mutant (KL), the upstream kinase for AMPK, lung tumours, compared with either lung cancer subtypes of KRAS (K) or concomitant KRAS and TP53 mutation (KP) from TCGA database (Fig. 1d). This evidence concerns the gene STK11 and lung cancer.