PROX1 and neoplasm: Using adeno-associated virus (AAV) serotype 8-mediated liver-specific expression of S79A/S79E and Cre in Prox1f/f mice, we found that the mice harbouring the nonphosphorylated PROX1 mutant (S79A) exhibited more tumour numbers and an increased liver-body ratio compared to the control and S79E mice (Fig. 6d–f).