While the silencing of circAnkib1 and circCsnk1g3 showed a profound effect on tumor growth in vivo, the silencing of linear Ankib1 and Csnk1g3 transcripts with shRNAs specific to the linear isoforms (Fig. 1i) did not impact tumor growth (Fig. 1j). The gene discussed is CSNK1G3; the disease is neoplasm.