Consistently, we found increased expression of interferon-related genes (e.g., Ifit3, Isg15, Ifih1, Oasl2, and Irf7) and pro-inflammatory cytokines (e.g., Cxcl10, Cxcl9, Ccl3, and Ccl5) in the tumor cells upon circAnkib1 and circCsnk1g3 silencing; these results were validated by RTqPCR for selected genes (Fig. 2b). Here, ISG15 is linked to neoplasm.