RIGI and sarcoma: Upon immunoprecipitation of RIG-I, RTqPCR on the pulled-down material demonstrated enrichment of circCsnk1g3 and circAnkib1 (Fig. 3d, Supplementary Fig. 3F), whereas no enrichment was observed for the linear transcripts, nor for circBnc2 (Supplementary Fig. 3F)—this result was consistent with the observation that circBnc2 does not regulate interferon signals in the sarcoma cells (Fig. 2b), and does not promote tumor growth (Fig. 1e, g).