RETN and obesity due to melanocortin 4 receptor deficiency: Obesity also induced considerable changes in the secretomes of PVAT (Fig. 3c, d), with several well-established adipokines—such as adipsin (Cfd), resistin (Retn), complement C1q and tumour necrosis factor-related protein 9 (C1qtnf9) and retinol-binding protein 4 (Rbp4)—being significantly dysregulated compared to wt mice (green spots in Fig. 3d, Supplementary Data 2).