MYC and esophageal squamous cell carcinoma: While the previous finding suggested that nearly 20% of ESCC and 30% of EAC bearing MYC gene dysregulation, gene set enrichment analysis (GSEA) of the TCGA ESCA datasets revealed that MYC signature is one of the top enriched gene signatures in NAA10Hi tumors compared with NAA10Low samples (Fig. 2D).