These findings documenting a switch in genes expressions such as Hmga1 and Csp1 (Hep-Par1) could be informative for future studies exploring the identity of cells in the context of the inter- and intra-tumoral heterogeneity of HCC patients, of the dynamics in cell population changes during treatment, and particularly in relation to the emergence of resistant subpopulations. This evidence concerns the gene HMGA1 and hepatocellular carcinoma.