Furthermore, more individuals recovered from severe and critical COVID-19 showed reduced frequencies of central memory (CM) CD4+ and CD8+ T cells (defined as CD45RA−CCR7+CD27+) (Bonferroni-adjusted P-value range 0.02–7.61 × 10−6) (Supplementary Fig. 9f). The gene discussed is CD8A; the disease is COVID-19.