Finally, FUr-induced full-length p53 was transcriptionally active and triggered p53-dependent cell death in human cancer cells carrying R213X nonsense mutant TP53. These results raise the possibility that tumors carrying nonsense mutant TP53 may be more sensitive to treatment with 5-FU and suggest that FUr itself should be explored as a therapeutic agent for such tumors. This evidence concerns the gene TP53 and cancer.