Western blot and IP results showed that the total expression of YME1L1 in the LPS‐induced septic AKI mouse model did not change significantly compared with that in the control group, but the acetylation level was increased, while the acetylation level of YME1L1 was further increased by Sirt3 deletion (Figure 8A–C). This evidence concerns the gene SIRT3 and acute kidney injury.