For example, Ajebli et al. conducted a review of natural alkaloids and mentioned that these have a therapeutic effect on the treatment of diabetes through actions such as the blockade of protein tyrosine phosfatase 1B and the deactivation of dipeptydil peptidase-IV, increasing insulin sensitivity, modulating oxidative stress, and the inhibition of the enzyme α-glucosidase [28,29,30,31]. The gene discussed is INS; the disease is diabetes mellitus.