Since dysfunctions of protein kinases are involved in the pathogenesis of several diseases, including solid or hematologic cancers and cardiovascular, autoimmune, and inflammatory diseases, protein kinase inhibitors (PKI) have triggered a large number of research programs within academia and pharmaceutical companies worldwide, leading to a regular approval of these drugs by the regulatory authorities. This evidence concerns the gene WEE1 and hematopoietic and lymphoid cell neoplasm.