Lee et al. (2016), analyzing the association between CYP polymorphisms and blood concentrations of hydroxychloroquine (HCQ) and its metabolite N-desethyl HCQ (DHCQ) in Korean patients with lupus, observed that patients with the GG genotype of allele *10 had the highest [DHCQ]/[HCQ] ratio, while patients with genotype AA had the lowest ratio [52]. Here, PPIG is linked to systemic lupus erythematosus.