NR1I2 and colorectal carcinoma: A study involving 109 advanced CRC patients receiving 180 mg/m2 irinotecan treatment highlighted a correlation between severe hematological toxicity and NR1I2-rs10934498-A (OR:0.17, p = 0.009), NR1I2-rs2472677-G (OR:41.55, p = 0.003), NR1I2-rs3814055-T (OR:9.25, p = 0.005), and NR1I2-rs1523127-C (OR:7.23, p = 0.009) alleles.