TAMs-related functions are also regulated by several genes, including C-C motif chemokine ligand 2 (CCL2), C-C motif chemokine ligand 18 (CCL18), TANK-binding kinase 1 (TBK1), and IFN regulatory factor 3 (IRF3), whose signaling pathway is activated during tumor angiogenesis. This evidence concerns the gene IRF3 and neoplasm.