Another study involving 125 metastatic or relapsed CRC patients treated with first-line cytotoxic chemotherapy combined with bevacizumab correlated the CXCL8-rs4073-T allele to a tendency for longer PFS, whereas it was significantly associated with better ORR compared to the AA genotype (OR:0.394, p = 0.067) [51]. Here, CXCL8 is linked to colorectal carcinoma.