NeuN immunoreactivities in the CA1 subfield (Figure 2G) and DG (Figure 2H) of the hippocampus decreased significantly by 21% (p < 0.05) and 41% (p < 0.05), respectively, in 3–4-month-old APP/BIN1/COPS5 3xTg-AD mice compared to wild-type controls. This evidence concerns the gene BIN1 and Alzheimer disease.