Next, to determine whether Nosustrophine treatment affected AD-related gene expression post-AD-associated neuropathological damage, we analyzed PSEN1, PSEN2, APOE, MAPT and ABCB7 mRNA expression in the 8–9-month-old Nosustrophine- and saline-treated-APP/BIN1/COPS5 mouse hippocampus. Here, APOE is linked to Alzheimer disease.