Considerable evidence from recent studies has demonstrated that there are lots of oncoproteins (such as phosphorylated epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), stromal-cell-derived factor 1 (SDF1), etc.)and oncogenic RNA (in particular miRNAs) in TEVs, making a contribution to tumor growth, invasion, migration and angiogenesis [31,32,33,34]. The gene discussed is VEGFA; the disease is neoplasm.