CD8A and neoplasm: For instance, engineered BMVs with the expression of IL-10 on the surface and the encapsulation of HPV16 E17 protein into them have been demonstrated to prevent the exhaustion of T cells, presentation of p-MHC I complexes and activation of CD8+ T cells transforming into CTLs, causing the inhibition of tumor growth and metastasis and implying a novel tumor immunotherapeutic strategy [60].