CD274 and neoplasm: Taking some construction means as an example, Lian, Shu et al. designed cationic liposomes containing si-CD47 and si-PD-L1 and modified them with EpCAM (epithelial cell adhesion molecule), so they not only enhanced the immune therapeutic efficacy of liposomes, but also improved the targeting ability owing to the overexpression of EpCAM proteins in tumor cells [18].